Year 1 – Introduction to Neuroscience: Neurons, sensory organs, and the brain

Motivation: Our curriculum this year relies heavily on inputs from monastics involved in the ETSI, to build basic understandings of neuroscience and conceptual bridges to monastics’ Buddhist studies and practices. A driving motivation for the year’s curriculum draws from the mutual scientific and Buddhist concern with this question: What is sentience? Individual pedagogical sessions each are guided by their own related questions.

Curriculum

What do organisms need to know and do?
  • Big Questions: What is the nervous system made of? What are the principles on which nervous system activity is based?
  • Lectures
    • What do organisms need to know about the world?
  • Activities
    • Introduction of the teaching team, assign student working groups
    • Understanding the Brain and Mind: Perspectives from Buddhism and from Neuroscience
    • What is sentience?
What is neuroscience?
  • Big Questions: How do western scientists study the human brain, mind, and behavior? What can neuroscience teach us? What are its limitations?
  • Lectures
    • Overview of neuroscience, a multidisciplinary field
    • Modes of inquiry
  • Activity
    • Scientific method
    • Graphing exercise
What makes up the human brain?
  • Big Questions: What does the brain do and how does it work? How does the brain organize the huge streams of incoming information? Is consciousness an emergent property?
  • Lectures
    • Overview of the human brain
  • Central and peripheral nervous systems
    • Activity
  • Building brains
What is a nervous system?
  • Big Questions: How is the system organized to gather, transmit, and process information, then act on it? How do we convert physical energies into subjective experiences? What are the rules for organizing this information?
  • Lectures
    • What are nervous systems made of?
    • Components and connections
  • Activities
    • Mid-course review
    • Vocabulary quiz
Why is connectivity so important?
  • Big Questions: What is the neural basis for processing information? How do we learn? What guides our behaviors and actions?
  • Lecture
    • Neural connections
  • Activity
    • Brain charades
Why do brains evolve?
  • Big Questions: Why do brains and nervous systems of creatures differ? What can this tell us about organic design or about the human brain?
  • Lecture
    • Brain evolution, comparative anatomy
  • Activity
    • Form and function
Catch-up, overview, and synthesis
  • Recap of Big Questions
  • Final review, question and answer session
Exam, evaluation, and wrap-up
  • Review session
  • Study time
  • Final exam
  • Exam results, overall score, awards
  • Closing party

Year 2 – The science of knowing, understanding, and behaving

Motivation:  This year’s curriculum is motivated by the question of “How do we know?” How do we as living beings perceive and experience our worlds? But also, how do neuroscientists gain knowledge and understanding?
We use the visual system as an exemplar for how information is captured and processed.

Curriculum

Neuroscience: The science of knowing, understanding, and behaving
  • Big Questions: How has understanding of sentience and the brain developed in western science? Why is neuroscience so new, compared to physics or biology?
  • Lectures
    • Introduction to neuroscience
    • How do we know? Information acquisition and analysis
    • Sensory systems; Vision as a model
  • Activities
    • Introduction of the teaching team, assign student working groups
    • Re/training in use of clickers
    • Discussion: Weighing the evidence
The system: Structure and function
  • Big Questions: What do the nervous system do? Why have a brain?
  • Lectures
    • Overview of anatomy
    • Organization of the nervous system
    • Navigating the brain: Terms for orientation
  • Activities
    • Demo: Night vision goggles
    • Computer lab: Functional Neuroanatomy and Brain Tutor
Mechanics of vision: From the eye to the brain
  • Big Questions: How do we capture information about the world? Do our senses show
    us the “real world”?
  • Lectures
    • Anatomy of the eye and visual system in the brain
    • Reception and processing
    • Introduction to the scientific method
  • Activities
    • Case study of scientific method
Seeing things
  • Big Questions: How does the brain make sense of sensations?
  • Lectures
    • Pathways and principles
    • Object recognition and the role of context
  • Activities
    • Visual illusions
    • Change blindness
Neurodevelopment
  • Big Questions: If the brain is the most complex material phenomenon we know, how
    is it built?
  • Lectures
    • How a working brain is built: Components and processes
    • Principles: Plasticity, Darwinian processes
  • Activities
    • Prism goggles and vision adaptation
Introduction to social neuroscience
  • Big Questions: How do our sensations relate to experience? How are humans able to
    communicate and relate to others?
  • Lectures
    • Vision and the emotional brain
    • The face as an organ of communication
    • Facial communication: Expression and recognition
  • Activities
    • Set up for intersession
    • Learning materials
    • Study neuroanatomy

Year 3 – Getting down to basics: transmission, integration, and response

Motivation: The fundamental driver for this year’s curriculum is the question: How does the nervous system work? Biochemical, molecular, and computational levels of explanation are unfamiliar to most monastics, but are intimately tied in to modern neuroscience. We build toward next year’s question of how brain and body work together in experience and behavior.

Curriculum

Back to basics
  • Big Questions
  • Lectures
    • Introduction to Year 2
    • Core concepts in neuroscience
    • Dialogues on mind; Studying neuroscience
    • The withdrawal (or flexor) reflex: A full neural pathway
  • Activities
    • Introduction of the teaching team, assign student working groups
    • Re/training in use of clickers
    • Worksheet: Core concepts in neuroscience
    • Breakout groups / class discussion
    • Reflexes, spinal cord anatomy
Electricity in the nervous system
  • Big Questions: What is the role of electricity in the nervous system? How is it produced?
  • Lectures
    • Electricity in the brain
    • Action potentials: How neurons make electrical signals called
  • Activities
    • Movies of lab experiments
    • Discussion
    • Computer lab: Neurons in Action (from ion channels to action potentials)
Chemical neurotransmission
  • Big Questions: How do chemicals produce action in the body? Can they affect our conscious experiences?
  • Lectures
    • Chemical transmission
  • Activities
    • Manipulation of chemical neurotransmission–skin temperature
Integration and sensation
  • Big Questions: How are the myriad actions of individual neurons able to produce phenomena such as a percept? Does the nervous system act like a computer?
  • Lectures
    • How neurons integrate synaptic inputs
    • Nervous system in Tibetan medicine (Dr. Gyamtso)
  • Activities
    • Computer lab: From synapses to signaling
    • Mid-course clicker feedback session
Sensation, motor system
  • Big Questions: How do our peripheral senses inform the brain? Does the brain regulate all our behaviors?
  • Lectures
    • Somatosensory system
  • Activities
    • Sense of touch: 2-point discrimination task
    • Reflex modulation
Basal ganglia
  • Big Questions: How does brain activity drive our movements? How does the
    nervous system allow us to walk or react? Is all behavior conscious?
  • Lectures
    • Movement and the motor systems
    • Multiple motor systems in motor planning and motor control
  • Activities
    • Measuring electrical activity of muscles during motor tasks
    • Discussion
Posture and balance
  • Big Questions: What is proprioception? How do we know where we are in space?
  • Lectures
    • Sensorimotor control of posture balance
  • Activities
    • Balance control and multisensory integration
    • Sensory conflict and sensorimotor illusions
    • Movement and movement disorders
Set up for intersession
  • Activities
    • Final exam (clickers)
    • Exam results, overall scores, awards
    • Closing party

Year 4 – Emotions and memory

Motivation: This year we address subjective experience, asking “Where do our feelings and thoughts come from?” and “How do we learn and remember?” We build a neuroscientific view of emotions and their actions that speak directly to monastics’ understanding of them as inherently afflictive, and discuss the neuroscience of addiction to engage Buddhist emphasis on craving as the root of affliction. Neuroscience identifies the grounds for empathy. How does this fit in to the picture?  

Curriculum

Introduction
  • Big Questions: What are the scientific methods behind neuroscience? What role does the brain play in what we know and feel?
  • Lectures
    • Emotions and memory
    • How do we know? Methods and logics in neuroscience
  • Activities
    • Introduction of the teaching team, assign student working groups
    • Neuroanatomy programs
    • Using brain imaging data
How the brain produces emotion
  • Big Questions: How are emotions produced? What is the relationship of emotion and consciousness?
  • Lectures
    • Emotions and the brain (systems)
    • Emotions and the brain: The example of fear
  • Activities
    • Functional neuroanatomy software
    • The case of Phineas Gage
    • Steps 1-5 of Day 5 memory task
Afflictions of emotion
  • Big Questions: Are emotions inherently afflictive? What causes addiction? Can addiction be cured?
  • Lectures
    • Reward systems in the brain and addiction
    • Afflictive emotions and drug addiction
    • Nervous system in Tibetan medicine (Dr. Gyamtso)
    • Depression
  • Activities
    • How do you recognize depression?
Memory
  • Big Questions: How do we learn and remember?
  • Lectures
    • Introduction to memory
    • Physiology of memory
  • Activities
    • Vocabulary quiz
    • Review
Emotion and memory in action: survival and sociality
  • Why do emotion and memory have synergistic or conflicting effects in our
    behavior? How do they help us be social?
  • Lectures
    • Emotion and memory in action: Survival and sociality in non-human
      animals
    • Emotion and memory in action: Survival and sociality in humans
  • Activities
    • Short term memory: analysis of data from Day 2
Emotion sharing and understanding
  • Big Questions: How is it possible to know what someone else is feeling or
    thinking? Is it possible or desirable to eliminate emotions?
  • Lectures
    • Empathy and compassion
  • Activities
    • Mind in the Eyes Task
    • Research design: How effective are methods for cultivating empathy?
Catch-up, overview, and synthesis
  • Recap of Big Questions
  • Final review, question and answer session
Exam, evaluation, and wrap-up
  • Review session
  • Study time
  • Final exam
  • Exam results, overall score, awards
  • Closing party

Year 5 – Mind/Body and internal regulation

Motivation:  This year we take up neuroscientific insights on issues of self regulation, relationships with the world, and the grounds of suffering and resilience, and self transformation. We further explore questions about relationships of mind/brain and body, and how they work together in relating to and managing our internal and external circumstances. These big questions are explored through examination of biorhythms, resting states, attention regulation, and stress response systems. The discovery of neuroplasticity is probed. And monastics explore how brain plasticity sets the foundation for self transformation through practices such as meditation. Students engage in activities and experiments with heart rate monitors to explore these issues.

Curriculum

Regulation and adaptation
  • Big Questions: How does the body/brain coordinate with external conditions to both accommodate challenges or opportunities and maintain well-being?
  • Lectures
    • How do we know? Subject and object of inquiry in science and Buddhism
    • Links between brain/mind and body
  • Activities
    • Introduction of the teaching team, assign student working groups
    • Cell phones and introduction of mood data collection
Biorhythms
  • Big Questions: How does the body/brain accommodate rhythms in nature such as day/night or seasons?
  • Lectures
    • Biological rhythms
  • Activities
    • Heart rate monitors
    • Motor memory (part 1)
    • Debate: All neurons are the same (paired debate)
Resting states
  • Big Questions: Why do we sleep and dream? What is sleeping?
  • Lectures
    • Waking and sleeping
  • Activities
    • Motor memory (part 2)
    • Guess the sleep stage
    • Download heart rate monitor data; Begin analyses
Tuning in and tuning out
  • Big Questions: How does the brain juggle all the different functions that it has? Is the brain composed of specialized parts that work together like a clock?
  • Lectures
    • Brain networks; Resting and attention
    • Exploring brain networks during meditation
  • Activities
    • Debate: Defend Buddhist and neuroscience views on memory (group
      debate)
    • Analyze daily heart rate data
    • Analyze heart rate data from debate
Meeting challenges
  • Big Questions: How do brain and mind relate to ongoing bodily processes? What is stress? Is stress harmful? What is pain and where does pain come from?
  • Lectures
    • Meeting challenges: The stress response and health
    • Affiliation and social relationships
  • Activity
    • Enter mood data, test hypotheses
The power of place and practices
  • Big Questions: Can early experience and everyday practices change our brain and thus experiences? If so, how and how lasting are the effects?
  • Lectures
    • Power of context: Experience and life course development
    • Effects of personal practices on the brain
    • Power of practice: Meditation effects on the brain
  • Activities
    • Broad discussion on Buddhist ideas about concepts, self, etc.
    • Meditation and heart rate
    • Debate: The brain you were born with determines what you can learn and
      do
Catch-up, overview, and synthesis
  • Recap of Big Questions
  • Final review, question and answer session
Exam, evaluation, and wrap-up
  • Review session
  • Study time
  • Final exam
  • Exam results, overall score, awards
  • Closing party

Year 6 – The mind at work / Doing science

Motivation: The final year brings it all together in understanding cognition and subjective experience. Students also participate in a thorough analytic review of the scientific process, as they design, implement and present a capstone project. The motivating questions for them are intellectual (What does neuroscience tell us about how we think and understand? How do these parallel or diverge in neuroscience or Buddhism?) and practical (What can I know through neuroscience?) Instructors work intensively with project groups at each step of the research process. Importantly, students learn the pursuit of meaningful scientific inquiry with limited resources. Lecture/discussions and projects are interwoven in successive sessions. We see all these as final steps to independent inquiry on students’ own terms.

Curriculum

Scientific thought
  • Big Questions: How do we know, in all senses? What are the logic and limits of scientific inquiry? How do science and Buddhism agree or disagree on criteria for validity?
  • Lectures
    • Scientific thought
  • Activities
    • Introduction of the teaching team, assign student working groups
    • Project planning: Rubrics and work group assignments
    • Debate: Planning
Concepts
  • Big Questions: What are concepts? Where do they come from? What is their role in thinking?
  • Lectures
    • Concepts: Introduction and structure
    • Concepts: Function and processing
  • Activities
    • Projects: Introduction and methods
    •  Projects: Design and methods
    • Lego building (memory task)
Remembering
  • Big Questions: How do we remember things? Is memory like a recording or
    movie? What can distort memory? Can memory be improved?
  • Lectures
    • Memory as reconstruction
  • Activities
    • Projects: Data collection
    • Lego building (reconstruction from memory task)
    • Lego memory task data analysis
Reasoning
  • Big Questions: How do we reason and make decisions? What are the grounds for valid conclusions? What are causes of distorted reasoning?
  • Lectures
    • Reasoning in the world
    • Reasoning: Buddhism vs. cognitive science
  • Activities
    • Projects: Data analysis and write-up of results
    • Reasoning (IAT)
Language
  • Big Questions: Why is it that humans use language? What makes this possible? Is language related to thought? Do people with different languages think differently?
  • Lectures
    • Language
  • Activities
    • Debate planning (formulate questions, arguments)
    • Paired debate: Concepts
    • Write-up of debate
The self
  • Big Questions: What is the self? Are there material/neuroendocrine bases for the self? Can self be useful? Is it possible or desirable to eliminate the sense of self?
  • Lectures
    • The self
  • Activities
    • Broad discussion on Buddhist ideas about concepts, self, etc.
    • Projects: Write-up of results
Present and discuss research projects
  • Big Questions: Why is critical evaluation so important in science? Are there
    similarities in Buddhist thought and practice? What are the scientific criteria for valid conclusions?
Review
  • Review session
  • Study time
  • Final exam
  • Exam results, overall score, awards
  • Closing party